定义组织损伤标准的一种方法显示,带变形值是多模式的
Callan M Luetkemeyer1, Corey P Neu2, Sarah Calve3
1Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United States; Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Acta biomaterialia
|July 11, 2023
概括
新的方法揭示了多种变形类型,而不仅仅是纤维应变,导致带等软组织的原损伤. 这一发现有助于确定伤害标准,以便更好地诊断和预防伤害.
科学领域:
- 生物力学 生物力学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 软组织损伤是由于过度拉伸而导致的细胞外基质损伤造成的.
- 目前对组织变形值的理解受到缺乏测量异质损伤和变形的方法的限制.
- 现有的模型通常假设原体损伤仅由纤维方向沿线的应变驱动.
研究的目的:
- 开发一种全领域的方法来定义使用多式模式应变极限的组织损伤标准.
- 为了建立在软组织中机械驱动的纤维状原蛋白脱化的应变值.
- 调查各种变形模式对小鼠中间侧带 (MCL) 中的原脱的贡献.
主要方法:
- 开发了一种新的全场方法来测量区域多式联运变形和损伤.
- 利用小鼠MCL作为模型组织来确定菌株值.
- 分析数据以确定机械驱动的原体变质的预测因素.
主要成果:
- 多种变形模式有助于在小鼠MCL中的原体变性.
- 水静压被确定为原体变质化的最佳预测因素,挑战了传统观点.
- 证明原体变性不仅仅是由纤维方向的应变驱动的.
结论:
- 软组织中的原变性可以由多种变形方式驱动.
- 拟议的方法允许从异质数据定义变形值.
- 这些发现将推动基于机械的诊断成像,损伤建模和易感性研究.
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