在移植接受者中,在COVID-19感染期间修改免疫抑制方案
Mahmoudreza Moein1, Samuel J Martin1, Carter Whittemore1
1Department of Surgery, Division of Transplantation, SUNY Upstate Medical University, Syracuse, NY, USA.
Transplant immunology
|July 11, 2023
概括
在COVID-19的移植患者中,尽量减少免疫抑制药物的使用,不会对长期的功能造成损害. 这一策略可能有助于减少住院的影响,尽管疲劳仍然是一个常见的感染后症状.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 流行病对全球健康产生了重大影响,尤其是对移植患者等弱势群体.
- 移植脏患者需要谨慎管理免疫抑制疗法,特别是当感染COVID-19等感染时.
研究的目的:
- 为了研究COVID-19对移植患者的影响.
- 分析免疫抑制药物修改对患者结果的影响.
- 评估COVID-19感染后的功能和生活质量.
主要方法:
- 一个前性收集的数据库的回顾性分析.
- 包括COVID-19的成年移植患者 (2020年1月至2022年12月).
- 免疫抑制减少的患者与不改变治疗方案的患者之间的比较.
主要成果:
- 分析了188名患者,76%的患者免疫抑制降低.
- 两组之间长期功能 (eGFR,血清肌素) 没有显著差异.
- 住院和ICU入院率没有显著差异,尽管ICU率在免疫抑制降低的情况下更高.
- 生物检测证明的排斥率在两组之间相似 (6对3次).
- 疲劳 (43.9%) 是COVID-19后最常报告的症状.
结论:
- 在患有COVID-19的移植患者中,尽量减少免疫抑制药物的使用,对长期功能是安全的.
- 这种策略可以在住院期间减轻急性疾病的严重程度.
- 完全康复并不普遍,疲劳是普遍存在的长期症状.
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