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Updated: Jul 23, 2025

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通过优化基于分子相互作用机制的聚合物和表面活性剂来增强里瓦罗克萨班载荷微球的口服生物利用性

Min-Jong Choi1, Mi Ran Woo2, Kyungho Baek1

  • 1Department of Pharmaceutical Engineering, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, South Korea.

Molecular pharmaceutics
|July 11, 2023
PubMed
概括

用聚乙烯 (PVP) 和酸 (SLS) 配制的微球显著提高了里瓦洛克萨班 (RXB) 的溶解性,溶解性和口服生物利用性. 最佳的药物辅助剂比率是成功开发利瓦洛克萨班配方的关键.

关键词:
微球微球是指一个微球.分子相互作用分子相互作用.口服生物可用性 口服生物可用性水溶性较差的药物 在水溶性较差的药物里瓦罗克萨班 (Rivaroxaban) 是一个

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