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循环曼诺化的促销者控制合成和构造分析,最多为32米尔

Xiaona Li¹, Cristina Di Carluccio², He Miao¹

¹Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.

Angewandte Chemie (International ed. in English)

|July 11, 2023

概括

研究人员开发了一种新方法来制造大型循环曼诺化物,包括32米尔聚曼诺化物,这是迄今为止最大的合成循环多糖. 这一突破扩大了复杂碳水化合物合成和药物输送应用的可能性.

科学领域:

碳水化合物化学碳水化合物化学
超分子化学超分子化学
药物输送系统药物输送系统

背景情况:

环极素是有价值的药物载体,因为它们的宿主特性和生物相容性.
合成各种大小和形状的大型循环寡糖仍然是一个重大挑战.
狭窄的形状空间阻碍了超大双功能糖前体的循环糖基化.

研究的目的:

开发一种促进剂控制的环糖化方法,用于合成超大周期性曼诺酸.
为了研究循环α-(1→6) 结合的曼诺酸的合成,研究了高达32mer.
为了探索合成的循环曼诺的构造性行为.

主要方法:

使用促进子控制,对双功能硫糖化物和 (Z) - 氨酸酸的循环糖化.
利用一个金I) 复合物作为一个关键的促进者来预先组织周期性过渡状态.
使用NMR光谱学和计算研究对合成的循环曼诺化物进行表征.

主要成果:

成功合成周期性α-(1→6) 结合的曼诺,可达32米尔.
获得了最大的合成循环多糖化物 (32默聚曼诺酸).
促销者身份,特别是黄金 (((I) 复合物,对循环甘化效率产生了重大影响.
合成的循环曼诺基体 (2-mer到32-mer) 呈现出不同的构造状态和形状.

结论:

一种新的促进剂控制的环糖化策略使得前所未有的大型循环曼诺基的合成成为可能.
黄金 (I) 复合体对于高效形成超大循环结构至关重要.
这些合成循环多糖的形状多样性为量身定制的应用提供了潜力.

关键词:

碳水化合物碳水化合物合规分析合规分析循环性橄糖化合物循环性橄糖循环糖化化循环糖化.葡萄糖基酶化是什么? 葡萄糖基酶化

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