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在头部和部重建性皮肤片中出现的第二次初级瘤的临床和病理特征

Kohtaro Eguchi¹, Kenya Kobayashi^1,2, Yoshitaka Honma³

¹Department of Head and Neck Surgery, National Cancer Center Hospital, 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

Scientific reports

|July 11, 2023

概括

皮肤重建片 (SNAFs) 中的第二次主要瘤正在增加. 这些缓慢生长的瘤有良好的预后,但诊断可能具有挑战性,通常需要重复活检.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
手术病理学手术病理学

背景情况:

由于头部和部重建和癌症存活率增加,皮肤重建片 (SNAFs) 中的第二次原发性瘤的发生率正在上升.
临床病理遗传特征,预后和SNAF的最佳治疗仍然存在争论和诊断上的挑战.

研究的目的:

追溯分析SNAFs的临床病理和遗传特征.
评估与SNAFs相关的诊断挑战和预后因素.

主要方法:

在20年内对21名SNAF患者进行活检的回顾性分析.
分类为癌 (FC) 和癌前病变 (PL).
通过下一代测序对p53和p16进行免疫组织化学分析,并通过下一代测序对TP53进行测序.

主要成果:

7名患者患有FC,14名患有PL;平均潜伏间隔分别为114个月和108个月.
病变是异构的,具有炎症的侧膜. 改变的p53在FC中为43%和PL中为29%;p16阳性在FC中为57%和PL中为64%.
在FC中,TP53突变为17%,在PL中为29%. 大多数FC患者存活下来,特别是那些没有免疫抑制的患者.

结论:

SNAFs呈现为具有炎症的异体瘤,其特征是相对较低的改变p53/TP53率和高的p16阳性.
这些瘤生长缓慢,预后一般良好.
困难的诊断需要考虑重复或切除活检.

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