作为一种可穿戴的衍生功能,CARE将昼夜振幅与人类认知功能联系起来
Shuya Cui1,2, Qingmin Lin3, Yuanyuan Gui1,2
1State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
NPJ digital medicine
|July 11, 2023
概括
一个新的可穿戴指标,即日间活动节律能量 (CARE),准确地测量日间频率. 关怀与认知功能有关,并具有遗传基础,为改善昼夜健康干预提供了潜力.
科学领域:
- 时间生物学 时间生物学
- 可穿戴技术可穿戴技术
- 认知神经科学 认知神经科学
- 遗传学 遗传学 是一个
背景情况:
- 循环节律调节重要的生理和行为过程.
- 黑色素是一种标准的,但昂贵的昼夜振幅测量方法.
- 可穿戴活动数据提供了一个替代方案,但相对广度容易导致行为掩盖.
研究的目的:
- 引入和验证循环活动节律能量 (CARE) 作为循环频幅的基于可穿戴设备的新型度量.
- 评估CARE与青少年和成人认知功能之间的关联.
- 研究CARE对认知表现的遗传基础和因果关系.
主要方法:
- 从可穿戴活动数据中推导出CARE,并将其与健康成年人的黑色素幅度进行验证.
- 在大量青少年 (SCHEDULE-A) 和成年人 (英国生物银行) 队列中分析了CARE与认知功能的关联.
- 进行了全基因组关联研究 (GWAS) 和门德尔随机化 (MR) 分析,以探索遗传关联和因果关系.
主要成果:
- CARE与黑激素振幅 (r=0.46,P=0.007) 有显著的相关性,证实了它的有效性.
- 在青少年 (β=30.86,P=0.016) 和成年人多重认知功能 (P<0.001) 中,CARE与全球执行综合功能相关.
- GWAS确定了CARE的遗传位点,MR分析表明CARE对推理,短期和前性记忆的显著因果作用 (P<0.0001).
结论:
- CARE 是一种有效且有效的基于可穿戴设备的昼夜振幅度指标,克服了现有指标的局限性.
- 根据CARE的测量,循环时振幅对各个年龄组的认知功能有显著的关联和因果关系.
- CARE具有强大的遗传基础和临床相关性,支持其在未来的昼夜研究和干预中使用.
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