牙周炎与成年人的认知障碍之间的关联
Lata Goyal1, Shipra Gupta2, Yeshwanth Perambudhuru1
1Periodontics Division, Department of Dentistry, All India Institute of Medical Sciences, Bathinda, India.
Evidence-based dentistry
|July 11, 2023
概括
这一系统性审查发现牙周病与成人认知障碍之间存在强烈联系. 需要进一步的研究,以了解连接牙疾病与痴呆和阿尔茨海默病的确切机制.
科学领域:
- 神经科学是一个神经科学.
- 口腔健康 口腔健康
- 公共卫生 公共卫生
背景情况:
- 牙周病,常见的口腔感染,越来越多地被怀疑会影响全身健康.
- 认知障碍,包括痴呆症和阿尔茨海默病,代表着日益严重的全球健康挑战.
- 了解口腔健康和神经疾病之间的潜在联系对于预防策略至关重要.
研究的目的:
- 系统地审查和总结调查牙周病与成人认知障碍之间的关联的观察性研究.
- 综合目前关于牙周炎和神经退行性疾病之间关系的证据.
主要方法:
- 在PubMed,Web of Science和CINAHL上进行了系统的文献搜索,截至2021年9月.
- 包括的研究是观察性 (队列,横截面,病例对照) 专注于患有牙周炎和没有牙周炎的成年人 (≥18岁).
- 使用适应的纽卡斯尔-太华尺度评估了方法质量,并包括了表明高质量的研究.
主要成果:
- 最终分析中包括了11项高质量的研究.
- 慢性牙周炎 (≥8年) 与更高的痴呆风险有关.
- 牙周病,炎症生物标志物和特定抗体的临床测量与认知障碍有积极的联系.
结论:
- 牙周病与认知障碍之间存在显著的关联.
- 长期的牙周炎可能会增加认知能力下降和神经退行性疾病的风险.
- 这种关联背后的精确生物机制需要进一步研究.
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