胎儿对大麻素 (CBD) 的暴露会改变热性疼痛敏感性,问题解决能力和前额叶皮层刺激能力
Karli S Swenson1, Luis E Gomez Wulschner2, Victoria M Hoelscher2
1Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Molecular psychiatry
|July 11, 2023
概括
在小鼠中,胎儿接触大麻 (CBD) 会改变后代的神经发育和行为. 男性后代显示疼痛敏感度增加,而女性在解决问题和改变神经元功能方面表现出缺陷.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 怀孕期间的恶心影响了许多女性,可以用大麻 (CBD) 治疗.
- 对于CBD对胎儿发育和产后结果的影响尚不清楚.
- CBD与关键的神经发育受体相互作用,如血清素 (5HT1A),Kv7和TRPV1.1.
研究的目的:
- 研究胎儿CBD暴露对小鼠神经发育和产后行为的影响.
- 测试怀孕期间CBD暴露会改变后代大脑发育和行为的假设.
主要方法:
- 怀孕的小鼠从胚胎第5天到出生时每天服用CBD (50mg/kg) 或载体.
- 后代的行为,包括疼痛敏感性和解决问题的能力,在成年后被评估.
- 对来自女性后代的前额叶皮层 (PFC) 神经元进行了电生理学记录.
主要成果:
- 胎儿CBD暴露通过TRPV1激活使成年男性后代对热痛敏感.
- 在产前暴露于CBD的雌性后代显示出减少解决问题的能力.
- 在女性中,CBD暴露改变了PFC中的神经元刺激性和突触功能.
结论:
- 产前CBD暴露会以特定性别的方式扰乱神经发育和产后行为.
- 观察到的行为和神经元变化表明胎儿CBD暴露的潜在长期后果.
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