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Updated: Jul 23, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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缺口信号通过抑制PGC-1α和线粒体生物生成来调节代谢开关在非分化的脂质瘤中

Pei-Chieh Tien1, Xiyue Chen1, Bennett D Elzey2,3

  • 1Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA.

Oncogene
|July 11, 2023
PubMed
概括

在非分化脂肪瘤 (DDLPS) 中的痕信号激活抑制PGC-1α,抑制线粒体功能并促进癌症生长. 恢复PGC-1α可以扭转这些影响,为这种致命的癌症提供潜在的治疗点.

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