在心室动的内心和心表双心室映射过程中对电活动的复杂性分析
Vasanth Ravikumar1, Xiangzhen Kong1, Nick Y Tan2
1Department of Electrical Engineering, University of Minnesota, Minneapolis, USA.
概括
心室动 (VF) 呈现出明显的空间和时间电气组织. 内心脏表现出无组织的,快速的活动,而心上表则在VF进展过程中表现出有组织的,较慢的电动模式.
科学领域:
- 心脏电生理学 心脏电生理学
- 计算心脏病学 计算心脏病学
- 节律失常的机制 节律失常机制
背景情况:
- 心室动 (VF) 是心脏突然死亡的主要原因.
- 目前的绘图技术限制了 in situ VF 时空分析的全面性.
研究的目的:
- 开发一种计算方法来描述使用商业技术的 VF 时空组织.
- 通过详细的电图绘制,调查VF基板和潜在的废弃目标.
- 在狗模型中在双心室映射期间评估心内电图.
主要方法:
- 开发了一种使用光学映射数据来区分有组织和无组织的电活动的线性差异分析 (LDA) 模型.
- 在VF期间在4只狗心脏中进行了双心室内心脏 (ENDO) 和副心脏 (EPI) 映射.
- 应用LDA,周期长度 (CL) 和规律指数 (RI) 到三次VF进展间隔的心内电图.
主要成果:
- 随着VF的进展,在上心脏 (EPI) 中观察到有组织的电活动,与内心脏 (ENDO) 相反.
- 内心,特别是右心室 (RV),表现出更短的周期长度 (CL),表明更快的VF活动.
- 在所有VF阶段,心上表皮表现出更高的规律性指数 (RI),表明了一致的时空电流模式.
结论:
- 在VF进展过程中确定了犬类心脏的独特电气组织和时空差异.
- RV内心的特点是高度失调和更快的VF频率.
- 心上表皮表现出高的时空组织和在VF期间的一致的,更长的RR间隔.
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