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伊比利亚半岛的E型肝炎病毒:系统性审查
Sérgio Santos-Silva1, Danny Franciele da Silva Dias Moraes2, Pedro López-López3,4
1ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Food and environmental virology
|July 11, 2023
概括
肝炎E病毒 (HEV) 在人类,动物和整个伊比利亚半岛的环境中传播. HEV-3是人类最常见的基因型,建议加强对猪和人类诊断的监测.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肝炎E病毒 (HEV) 是全球急性病毒性肝炎的重要原因,每年导致数百万例感染和数千例死亡.
- 在伊比利亚半岛内,在人类和动物群体中越来越多地发现了HEV感染.
- 对该地区的HEV流行病学有全面的了解,对于公共卫生干预至关重要.
研究的目的:
- 系统地审查和评估所有有关HEV的现有数据.
- 为了汇集来自于伊比利亚半岛的人类,动物和环境研究的信息.
- 评估该地区传播的HEV的流行率和基因型.
主要方法:
- 在Mendeley,PubMed,Scopus和Web of Science数据库中的系统文献搜索.
- 包括到2023年2月1日发表的研究.
- 应用PRISMA指南用于研究选择和数据提取,导致151篇符合条件的论文.
主要成果:
- 在伊比利亚半岛,在人类,动物和环境样本中检测到多种HEV基因型 (HEV-1,3,4,6) 和罗卡赫佩病毒.
- 在葡萄牙和西班牙,HEV-3是人类感染中占主导地位的基因型.
- 主要在旅行者和来自特有地区的移民中发现了HEV-1.
结论:
- 这些发现突出了在伊比利亚半岛传播的各种HEV基因型,需要有针对性的公共卫生战略.
- 鉴于西班牙的大量猪肉生产和HEV-3的动物感染潜力,建议在猪群中实施HEV监测,并将HEV纳入人类肝炎诊断.
- 建立一个强大的HEV监测机制对于了解疾病流行率,菌株多样性和公共卫生影响至关重要.
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