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老年人外耳黑色素瘤患者的预后诺莫图:基于SEER的研究

Xue Gong¹, Yang Zhang², Meng Yuan³

¹Department of Plastic Surgery and Burn, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Journal of cancer research and clinical oncology

|July 11, 2023

概括

这项研究开发了一种新的名图,用于预测老年外耳黑色素瘤患者的存活率. 该模型准确识别高风险个体,有助于个性化治疗策略.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
生物统计学生物统计学

背景情况:

外耳黑色素瘤 (EEM) 是一种罕见但具有攻击性的皮肤癌.
老年EEM患者的整体存活期 (OS) 的预测模型是有限的.
准确的预后工具对于指导这种人群的治疗决策至关重要.

研究的目的:

构建和验证用于预测老年EEM患者1年,3年和5年的OS的诺米克图.
在这个患者群体中确定OS的独立预后因素.
为个性化风险评估和治疗规划提供一个工具.

主要方法:

利用了来自监测,流行病学和最终结果 (SEER) 数据库 (2010-2014) 的数据.
采用单变量和多变量考克斯回归分析来确定重大风险因素.
基于独立预测器构建了一个名录,并验证了它的区分和校准能力.

主要成果:

总共有710名老年EME患者被分析,分为培训和验证队列.
关键的OS预测因素包括年龄,美国联合癌症委员会 (AJCC) 阶段,T阶段,手术和化疗.
诺米图表显示出良好的预测准确性 (C指数:培训时为0.78,验证时为0.72) 并有效地将患者分为高风险和低风险组.

结论:

一种新的,经过验证的名图有效地预测老年EEM患者的1年,3年和5年的OS.
这种个性化的预测工具提供了有价值的预后见解.
诺米图可以作为临床医生管理EME的老年患者的实用工具.

关键词:

年长的老人.外耳黑色素瘤外耳黑色素瘤这个名字叫做Nomogram.总体生存率总体生存率塞尔·塞尔 (Seer) 是一个看得见的人.

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