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高IL4I1表达与甲状腺癌的预后不佳和免疫透相关
Liying Zhu1, Jun Wang2, Jia'an Hu3
1Department of Geratology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197 Ruijin 2nd Road, Shanghai, 200025, China.
在甲状腺癌中增加的互白素-4诱导-1 (IL4I1) 表达与转移和不良预后相关. IL4I1可以作为预测生存的生物标志物和免疫治疗的目标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 甲状腺癌的死亡率通常与转移有关.
- 酶互白素-4诱导-1 (IL4I1) 已经涉及到瘤转移.
研究的目的:
- 为了研究IL4I1在甲状腺癌转移中的作用.
- 探索IL4I1与患者预后之间的关系.
主要方法:
- 对IL4I1mRNA表达的TCGA和GEO数据集的分析.
- 使用HPA进行IL4I1蛋白表达的评估.
- 对于诊断和预后价值的ROC和Kaplan-Meier分析.
- PPI网络构建,功能丰富和免疫透分析.
- 在体外实验证实IL4I1的生物效应.
主要成果:
- 在甲状腺癌中,IL4I1 mRNA和蛋白质表达显著上调.
- 较高的IL4I1表达与晚期恶性瘤,淋巴结转移和甲状腺外延伸相关.
- IL4I1表达预测了更糟糕的无进展生存期 (PFS).
- 在实验室中,IL4I1与免疫透有关,并促进了癌细胞的增殖,迁移和入侵.
结论:
- 增加IL4I1表达与瘤微环境 (TME) 中的免疫失衡有关.
- IL4I1 作为甲状腺癌预后不佳的潜在生物标志物.
- IL4I1代表了甲状腺癌免疫治疗的潜在治疗标.
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