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在risperidone过量后的患者中,对比剂引起的抗上腺素抗性过敏性休克:一个病例报告
Takafumi Nakano1,2, Yoshihiko Nakamura3, Keisuke Sato4
1Department of Pharmacy, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. naka0625@fukuoka-u.ac.jp.
过量服用Risperidone使过敏性休克复杂化,使得上腺素无效. 这种罕见的病例凸显了在过敏反应期间接受Risperidone治疗的患者需要考虑降低上腺反应的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 紧急医疗 紧急医疗
背景情况:
- 在日本,除了过敏反应外,与上腺素一起使用Risperidone是禁忌的.
- 有限的临床数据存在于RISPERIDONE和上腺素的相互作用.
- 这一病例涉及上腺素耐药性过敏性休克,其后是瑞斯佩里过量服用.
研究的目的:
- 报告一种罕见的抗上腺素过敏性休克病例.
- 为了研究RISPERIDONE过量剂和过敏反应治疗之间的相互作用.
- 突出对临床实践的潜在影响.
主要方法:
- 一位患有Risperidone过量剂量的患者在注射对比剂后发生过敏性休克.
- 最初的上腺素剂量在改善低血压方面无效.
- 治疗包括二碳酸,新鲜冷血和持续的上腺素输液.
主要成果:
- 患者经历了抗上腺素的过敏性休克.
- 多模式治疗后血压有所改善,包括持续的上腺素.
- 耐药性很可能是由于高血度的Risperidone.
结论:
- 这是一个罕见的Risperidone过量诱导的抗上腺素的过敏性休克病例.
- 高水平的RISPERIDONE可能会降低上腺素反应能力.
- 临床医生应考虑在接受Risperidone治疗的患有过敏反应的患者中减少上腺反应.
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