最近对与癌症相关的microRNAs营养免疫调节的最新见解
Teslime Özge Şahin1, Birsen Yılmaz2, Neslihan Yeşilyurt1
1Department of Nutrition and Dietetics, Gazi University, Ankara, Turkey.
Phytotherapy research : PTR
|July 12, 2023
概括
饮食选择显著影响癌症. 特定的食物和饮食可以改变microRNAs (miRNAs),通过调节免疫反应和基因表达来影响癌症预防和治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 癌症是全球主要的死亡原因,受到包括生活方式和营养在内的多因素的影响.
- 营养在癌症预防,发展和治疗中起着至关重要的作用,影响免疫系统在癌症中的炎症信号.
- 分子研究表明,绿茶,橄油,黄和大豆等食品中的生物活性化合物可以积极影响微RNA (miRNA) 表达.
研究的目的:
- 审查特定食物,饮食模式和生物活性成分对癌症的影响.
- 探索这些饮食因素如何调节与癌症相关的微RNA (miRNA) 表达.
- 通过miRNA调节讨论饮食干预在癌症预防和治疗中的作用.
主要方法:
- 对调查饮食和癌症分子机制的研究进行文献综述.
- 对生物活性化合物及其对miRNA表达的影响的研究分析.
- 检查有关饮食模式和癌症结果的流行病学和实验数据.
主要成果:
- 某些生物活性食品 (绿茶,橄油,黄,大豆) 可以积极改变参与癌症途径的miRNA表达.
- 饮食模式,如地中海饮食,显示抗癌效应,而高脂肪和甲基限制饮食可能会产生负面影响.
- 饮食引起的miRNA表达的变化与瘤和瘤抑制途径的调节有关.
结论:
- 针对miRNA表达的饮食干预措施代表了癌症预防和治疗的有希望的策略.
- 了解营养,免疫系统和miRNA调节之间的相互作用对于开发有效的癌症疗法至关重要.
- 基于miRNA调制的个性化营养策略可以增强癌症护理.
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