NAD的前体营养补充剂使大脑对未来的缺血事件敏感
Wensheng Qu1,2, Kenneth M Ralto3,4, Tao Qin2
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
概括
尼古丁胺胺氨基二核酸 (NAD+) 前体如NAM和NR在缺血性中风后给予时表现出神经保护作用. 然而,使用这些补充剂进行中风前治疗可能会通过改变细胞新陈代谢而使结果恶化.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 代谢过程中的代谢.
背景情况:
- 尼古丁胺胺二核酸 (NAD+) 对于细胞能量生产至关重要.
- NAD+前体,尼古丁胺 (NAM) 和尼古丁胺 рибоoside (NR),是受欢迎的补充剂.
- 以前的研究表明,关于缺血性中风中NAD+前体疗效的结果是相互矛盾的.
研究的目的:
- 研究NAD+前体对缺血性中风结果的双重影响.
- 为了比较NAM和NR的后缺血管理与前缺血管理的影响.
主要方法:
- 在小鼠中的中脑动脉封闭 (MCAO) 模型.
- 在再注血20分钟后或每天在MCAO前三天服用NAM或NR.
- 评估心脏病发作量,神经缺陷和关键代谢标志物 (AMPK,PGC1α,SIRT1,ATP).
主要成果:
- 单次后缺血剂量的NAM或NR改善了神经和组织的结果.
- 在三天内用NAM或NR进行的前缺血治疗加剧了中风的结果,增加了心脏病发作的大小.
- 经过缺血症后的NAD+前体的使用上调了AMPK,PGC1α,SIRT1和ATP,这种效果在缺血症前治疗中没有观察到.
结论:
- 在缺血性中风后进行治疗时,NAD+前体表现出神经保护作用.
- 用NAD+前体进行预治疗可能会使大脑对缺血产生敏感,可能会恶化结果.
- 在确定它们对缺血性中风的影响方面,NAD+前体的时间非常重要. 由NAD+前体诱导的潜在代谢变化可能解释这些差异效应.
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