多二和甲状腺功能:一个范围审查
Pouria Mohammadparast-Tabas1, Morteza Arab-Zozani2, Kobra Naseri3
1Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Reviews on environmental health
|July 12, 2023
概括
聚化双 (PCB) 暴露与动物模型中的甲状腺功能低下有关. 本综述综合了关于PCB对动物,鱼类和胚胎甲状腺激素的影响的证据,强调了对人类研究的需要.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 比较病理学比较病理学
背景情况:
- 多双 (PCB) 是持久性环境污染物,具有已知的内分泌干扰特性.
- 关于PCB暴露与甲状腺激素干扰之间的关联现有证据是相互矛盾的.
- 全面了解PCB对不同物种甲状腺功能的影响至关重要.
研究的目的:
- 进行范围审查和元分析,以澄清PCB暴露与甲状腺激素干扰之间的关联.
- 在动物模型中评估特定PCB同源对甲状腺激素的影响.
主要方法:
- 在PubMed,Scopus,Web of Science和Google Scholar (2010年起) 上进行系统的文献搜索.
- 包括研究PCB对甲状腺功能的影响的动物研究.
- 使用随机效应模型进行元分析,以评估TSH,TT4,TT3和FT4水平,并根据PCB类型进行子组分析.
主要成果:
- 在Aroclor 1260和PCB 126暴露时观察到TSH显著增加.
- 对Aroclor 1260,PCB 118,PCB 126和PCB 153的暴露显著降低了TT4水平.
- 暴露于PCB 118和PCB 153增加了TT3水平,而Aroclor 1254和PCB 126降低了TT3水平. PCB 126显著减少了FT4.4的使用.
结论:
- 暴露于PCB与各种动物模型中的甲状腺功能低下有关,包括动物,鱼类和胚胎.
- 这些发现强调了PCB在不同物种中破坏甲状腺的潜力.
- 进一步的大规模人类队列研究是有必要的,以调查PCB暴露与人类甲状腺功能障碍之间的关联.
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