在新生儿发育过程中,边缘电路的嗅觉驱动的β频带携带
Johanna K Kostka1, Ileana L Hanganu-Opatz1
1Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, Hamburg Center of Neuroscience (HCNS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
The Journal of physiology
|July 12, 2023
概括
新生儿嗅觉球在发育早期同步了边缘电路. 嗅觉输入驱动神经活动和贝塔同步穿过嗅觉球-侧面内皮质-海马体-前额外通路.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 感官系统 感官系统
背景情况:
- 认知处理取决于生命早期的边缘电路精细化.
- 嗅觉系统是新生儿的主要感官输入.
- 早期嗅觉处理在塑造新生儿边缘电路中的作用尚不清楚.
研究的目的:
- 调查早期的嗅觉处理如何影响新生儿发育期间的边缘电路活动.
- 为了确定嗅球是否同步新生儿的边缘电路.
主要方法:
- 在新生小鼠的嗅球,侧内皮质,海马体和前额皮质的同时体内记录.
- 嗅觉刺激,光遗传学和化学遗传学操纵的嗅觉球的/状细胞.
- 在两性未经麻醉的新生小鼠中进行的记录.
主要成果:
- 新生儿嗅觉球在贝塔频率范围内同步边缘电路.
- 嗅觉刺激增强了神经元和网络活动在侧侧内皮质,海马和前额叶皮质.
- 气味球细胞投射到海马 - - 投射侧侧内皮层神经元,驱动下游活动.
- 阻断侧侧内皮层投射的 mitra 细胞轴突中的囊释放,证实了侧侧内皮层在嗅觉球泡驱动电路引进中的作用.
结论:
- 新生儿嗅球活动对于同步边缘电路至关重要.
- 嗅球-横向内腔皮质-海马体-前额叶路径是在发育早期建立的.
- 嗅觉处理显著影响新生儿大脑的发育和在边缘回路内的沟通.
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