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皮克林乳液稳定与小糖氨酸功能化纳米钻石作为眼部药物输送应用程序的模型系统
Zhiwei Huang1, Roman V Moiseev2,3, Solomon S Melides1
1School of Mathematics and Physics, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK. j.keddie@surrey.ac.uk.
Soft matter
|July 12, 2023
概括
新的纳米钻石稳定皮克林乳液提供了改善的眼部药物输送. 这些生物相容的乳液在角膜组织上表现出增强的保留和无毒性,优于常规表面活性剂的选择.
科学领域:
- 纳米技术 纳米技术
- 生物材料是一种生物材料.
- 眼部药物输送 眼部药物输送
背景情况:
- 常规的油在水乳液用于眼部药物输送使用表面活性物质,这些表面活性物质可能会引起刺激,并导致眼部组织的不良保留.
- 由纳米颗粒稳定的皮克林乳液提供生物相容性,并越来越多地被用于生物医学应用.
研究的目的:
- 为了评估皮克林乳液稳定功能化纳米钻石用于眼部药物输送.
- 评估这些新型乳液的稳定性,生物相容性和眼组织保留.
主要方法:
- 使用纳米钻石 (ND) 纳米颗粒与双尾 (2T) 寡糖素功能化制造皮克林油在水乳液.
- 在中性pH下对三个月的乳液稳定性的评估.
- 使用ex vivo牛角膜透性和不透明性测试对ND-2T皮克林乳液无毒性的评估.
- 在角膜组织上测量油相保留,分析粘粘性质.
主要成果:
- ND-2T皮克林乳液的稳定性超过三个月.
- 乳液表现出与缓冲溶液相比的无毒性,在ex vivo角膜测试中.
- 由于2T功能化的粘粘性特性,观察到角膜组织上油相的保留显著增加.
- 配制的乳液具有与天然液相似的表面张力,pH值和盐度.
结论:
- 纳米钻石稳定皮克林乳液为眼部药物输送提供了一个有希望的,无毒的替代品.
- 由于粘膜凝固而增强的角膜保留比传统的表面活性剂系统具有显著的优势.
- 在这个模型系统中展示的原则对于未来的药物输送配方设计具有广泛的适用性.
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