11氧化在前列腺癌中的作用
Gido Snaterse1, Johannes Hofland2, Bruno Lapauw1
1Department of Endocrinology and Metabolism, Ghent University Hospital, Ghent, Belgium.
Endocrine oncology (Bristol, England)
|July 12, 2023
概括
与11-ketotestosterone一样的11-oxygenated androgens激活了雄激素受体,甚至在治疗后也可能推动前列腺癌 (PC) 的进展. 需要进一步的研究来澄清它们在割抵抗性前列腺癌 (CRPC) 中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 11-氧化激活受体 (AR) 在生理水平.
- 这些上腺衍生类固醇在雄激素剥夺疗法 (ADT) 后仍然存在,这使得它们与割抵抗性前列腺癌 (CRPC) 有关.
- 11-基托 (11KT) 是一种强大的AR激动剂,也是CRPC中主要的活性雄激素.
研究的目的:
- 审查目前的证据,将11-oxygenated androgens与前列腺癌 (PC) 联系起来.
- 要突出有关这些类固醇体内和临床作用的知识差距.
- 探索CRPC中11氧化的潜在临床意义.
主要方法:
- 对11氧化和前列腺癌现有研究的文献综述.
- 在CRPC中分析有关类固醇代谢和AR激活的体外发现.
- 评估当前的体内和临床证据,确定局限性.
主要成果:
- 实验室研究表明,CRPC适应促进了11氧化的内积累.
- 在循环中存在11-氧化,可以在PC细胞内转化为活性.
- 现有有限的体内和临床数据完全支持体外发现.
结论:
- 十一氧化因其AR激活特性而与前列腺癌 (PC) 进展有关.
- 在了解这些类固醇在割抵抗性前列腺癌 (CRPC) 的体内生理学和临床影响方面仍然存在重大差距.
- 需要进一步全面评估,特别是内度,以确定11-氧化对CRPC进展的确切贡献.
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