人类带病的全球流行:系统性审查和元分析
Luis Raúl Rosas-Hostos Infantes1, Guillermo Andres Paredes Yataco1, Yeimer Ortiz-Martínez2
1Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Perú.
Therapeutic advances in infectious disease
|July 12, 2023
概括
全球4.5%的人类带病,南美和非洲的发病率更高. 这种被忽视的热带疾病需要加强流行地区的监测和控制措施.
科学领域:
- 寄生虫学的寄生虫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 麻病是一种显著的寄生动物性 zoonosis,导致人类的发病率.
- 人类带病被世界卫生组织认定为被忽视的热带疾病.
- 人类带病的全球流行数据在很大程度上仍未知.
研究的目的:
- 为了估计人类带病的全球患病率.
- 为了确定带状菌病负担最高的地区和人口.
主要方法:
- 1985年12月至2022年10月期间发表的研究的系统综述和元分析.
- 包括使用适当的诊断方法对人类带病发病率的研究.
- 排除动物研究;使用JBI SUMARI进行质量评估;用于流行率估计的随机效应模型.
主要成果:
- 分析了来自15个国家的55项研究,涉及154,697名患者.
- 估计全球综合流行率为4.5% (95% CI:3.1-6.1).
- 患病率因地区而异 (南美9.0%,非洲4.8%,亚洲2.0%),在玻利维亚 (21%) 和秘鲁 (11%),患病率最高.
结论:
- 人类带病仍然是一个全球被忽视的热带疾病,估计患病率很高.
- 在儿童,南美研究和使用Fas2-ELISA时观察到更高的患病率.
- 加强流行病学监测和控制措施对于高度特有病区至关重要.
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