相关实验视频
Updated: Jul 23, 2025

09:41
Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
14.8K
在慢性病中,与正常血清二碳酸盐水平的隐性酸保留
1Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Electrolyte & blood pressure : E & BP
|July 12, 2023
概括
慢性病 (CKD) 中亚临床代谢酸性的早期性治疗可以预防功能下降. 目前缺乏指导方针,因此需要进一步研究这种CKD早期阶段的最佳治疗策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 生物化学 生物化学
背景情况:
- 在慢性病 (CKD) 中,对骨,肌肉和脏的健康至关重要.
- 亚临床代谢酸症,以与正常血清碳酸盐的隐性H+保留为特征,在CKD患者中可能会先发生明显的酸症.
- 这一早期阶段可能导致不适应反应和功能恶化,原因是尿酸分泌受损.
研究的目的:
- 审查了解CKD中亚临床代谢性酸性病的最新进展.
- 为了检查潜在的治疗策略,特别是疗法,对于患有eubicarbonatemic代谢酸性症的患者.
- 强调需要基于证据的指导方针,以启动性疗法和最佳的二碳酸盐水平.
主要方法:
- 对干预研究和最近发展的文献综述.
- 分析尿酸分泌在CKD进展中的作用.
- 检查早期H+保留的潜在治疗方法.
主要成果:
- 慢性病中的亚临床代谢酸症可能会导致功能下降.
- 早期调节酸平衡是预防CKD进展的潜在策略.
- 由于缺乏确定的指导方针,最佳的性治疗方法和目标仍然不确定.
结论:
- 进一步的研究是必不可少的,以建立强有力的指导方针,治疗在CKD的亚临床代谢酸症.
- 用正常的二碳酸盐水平解决隐藏的H+保留对于控制CKD进展至关重要.
- 针对早期酸不平衡的干预治疗对CKD患者显示出治疗潜力.
相关概念视频
Renal Regulation of Acid-Base Balance
522
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
522
Bicarbonate-Carbonic Acid Buffer
1.6K
The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:
1.6K
Diagnosing Acidosis and Alkalosis
272
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
272
Disorders of Acid-Base Balance
247
The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
247
pH Homeostasis
12.8K
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
Respiratory...
12.8K
Respiratory Regulation of Acid-Base Balance
474
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
474

