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对接受维持血液透析的患者进行额外的输血:回顾性分析
Wendong Li1, Jing Wang1, Yanqin Wang1
1Department of Nephrology, Baoji People's Hospital Baoji 721000, Shaanxi, China.
American journal of translational research
|July 12, 2023
概括
血液透析与输血和针相结合,改善了慢性病患者的和代谢和免疫功能. 这种联合疗法有效地管理完整的副甲状腺激素 (iPTH) 水平,而不会对营养状况产生负面影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内部医学 内部医学
- 生物化学 生物化学
背景情况:
- 和代谢障碍 (CPMD) 是接受维护血液透析的患者常见的并发症.
- 完整的副甲状腺激素 (iPTH) 和营养状况是患者结果的关键指标.
研究的目的:
- 评估在维护血液透析患者中,结合血液透析与血液输液和针治疗CPMD的疗效.
- 评估这种联合治疗对iPTH水平和营养状况的影响.
主要方法:
- 对142名接受维持血液透析的患者进行了回顾性分析.
- 对照组 (血液透析+针) 和研究组 (血液透析+输血+针) 的比较.
- 评估生化标志物 (iPTH,Ca,P,-产物,β2-MG,Scr,BUN),免疫功能 (IgG,IgM) 和营养指标 (Alb,PA,Hb). 评估生化标志物 (iPTH,Ca,P,-产物,β2-MG,Scr,BUN),免疫功能 (IgG,IgM),以及营养指标 (Alb,PA,Hb). 评估生化标志物 (iPTH,Ca,P,产物,β2-MG,Scr,BUN) 和营养指标 (Alb,PA,Hb).
- 使用 LASSO 回归的风险预测模型的开发.
主要成果:
- 与对照组相比,研究小组在治疗后显著降低了P,iPTH和-产品,并且与对照组相比,治疗后的Ca水平更高 (P<0.05).
- 输血组合导致降低β2-MG,Scr,BUN,并改善了Alb水平 (P<0.05).
- 研究小组观察到增强的免疫功能 (IgG,IgM);营养标志物保持稳定,与控制组不同,它们下降 (P<0.05).
- 一个风险评分模型显示了治疗疗效的高预测准确性 (AUC=0.991).
结论:
- 血液透析与输血和针相结合,有效调节免疫功能和-代谢,包括增加血液中的.
- 这种联合治疗不会对患者的营养状况产生不利影响.
- 该研究开发了一个基于关键临床参数的治疗疗效的预测模型.
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