凝血和纤维溶解功能指数和NET的预后值对于败血症患者
Yufeng Su1, Dagen Li1, Siyu Deng1
1Department of Laboratory Medicine, People's Hospital of Changshou Chongqing 401220, China.
American journal of translational research
|July 12, 2023
概括
中性粒细胞外细胞陷 (NETs) 和凝血标记在败血症患者中升高. 这些因素,特别是国际规范化比率 (INR),显示出对败血症预后和患者存活率的显著预测价值.
科学领域:
- 血液学 血液学 血液学
- 临界护理医学 临界护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染反应失调引起的.
- 凝血,纤维溶解和中性粒细胞外细胞陷 (NETs) 在败血症发病和预后中的作用需要进一步阐明.
研究的目的:
- 在败血症患者中调查NET和凝血/纤维溶解标记物的水平.
- 探索这些标志物在疾病识别和预后预测中的临床意义.
主要方法:
- 对120名败血症患者,120名细菌感染患者和120名健康对照者的回顾性分析.
- 测量了NETs,前热血素时间 (PT),纤维素 (FIB),D-二次体,国际规范化比率 (INR),APACHE II和SOFA分数.
- 评估了NETs对生存的相关性和预测价值.
主要成果:
- 与对照人群相比,败血症患者的血清NET,PT,FIB,D-二次体和INR水平显著更高.
- 净水平与APACHE II,SOFA分数,PT,FIB,D-二次数和INR正相关.
- INR在预测败血症患者28天死亡率方面表现强.
结论:
- NETs和凝血指数对于败血症预后具有很高的预测价值.
- 这些标志物可以帮助识别败血症的严重程度和预测患者的结果.
相关概念视频
01:09Coagulation
7.1K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
7.1K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
36
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
36
01:16Clot Retraction and Fibrinolysis
6.5K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.5K
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
202
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
202