高密度脂蛋白:什么时候重新考虑过多的好东西
Lily N Dastmalchi1, Charles A German2, Pam R Taub3
1Section of Cardiology, Department of Medicine, Temple University Hospital, Philadelphia, PA, USA.
American journal of preventive cardiology
|July 12, 2023
概括
高密度脂蛋白胆固醇 (HDL-C) 水平表明心血管疾病的风险,但它的功能是复杂的. 在HDL-C中使用.
科学领域:
- 心血管科学 心血管科学
- 脂质代谢 脂质代谢是什么
- 临床生物化学 临床生物化学
背景情况:
- 高密度脂蛋白胆固醇 (HDL-C) 传统上与动脉样硬化心血管疾病 (ASCVD) 风险有关.
- 较低的HDL-C水平 (男性<40 mg/dL,女性<50 mg/dL) 与ASCVD风险增加有关.
- 提高HDL-C的药理干预措施没有改善心血管结果.
研究的目的:
- 审查HDL-C在心血管疾病 (CVD) 风险评估中的复杂作用.
- 为了突出标准HDL-C测量的局限性.
- 讨论影响HDL粒子功能和有效性的因素.
主要方法:
- 临床试验和观察性研究的文献综述.
- 分析超越胆固醇水平的高密度胆固醇颗粒特征.
- 检查影响HDL功能的因素.
主要成果:
- HDL-C的心脏保护作用是复杂的,不仅仅是由度决定的.
- 高高的HDL-C (>90 mg/dL女性,>70 mg/dL男性) 可能会增加非心血管死亡率和感染风险.
- 高密度胆固醇颗粒的功能,大小,子类和胆固醇排泄能力各不相同,影响心血管疾病风险预测.
结论:
- 标准HDL-C水平可能无法完全捕捉一个人的心血管风险.
- 高密度LDL颗粒的功能是其动脉保护作用的关键决定因素.
- 需要进一步的研究来完善HDL-C在心血管疾病风险评估中的实用性,特别是在多样化的人群中.
相关概念视频
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
201
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
201
01:26Coronary Artery Disease IV: Preventive Measures
25
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
25
01:29Cholesterol: Significance and Regulation
592
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
592
01:18Lipids: Dietary Sources and Requirements
851
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
851
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
702
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
702
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
42
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
42