在PCSK9单克隆抗体与高血糖不良事件之间的关系方面取得了很大进展
Ruixing Zhang1,2,3, Yongxiang Wang2,3, Yu Peng2,3
1The First Clinical Medical College, Lanzhou University, Lanzhou, China.
Frontiers in cardiovascular medicine
|July 12, 2023
概括
长期使用蛋白转化酶亚素/素9型 (PCSK9) 单克隆抗体 (PCSK9-mAbs) 似乎不会增加高血糖不良事件 (HAE). 需要进一步的研究,但目前的数据表明PCSK9-mAbs和HAE之间没有联系.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 已知他类药物会增加高血糖不良事件 (HAE).
- 蛋白转化酶亚素/素9型 (PCSK9) 单克隆抗体 (PCSK9-mAbs) 是用于心血管疾病 (CHD) 的新型降脂药物.
- PCSK9-mAbs和HAE之间的关系仍然存在争议,各种研究的结果相互矛盾.
研究的目的:
- 审查目前关于PCSK9-mAbs和HAEs之间关联的证据.
- 为了澄清PCSK9-mAbs在血糖控制方面的安全性.
- 为了解决围绕PCSK9-mAbs和HAEs的临床问题.
主要方法:
- 分析来自FOURIER-OLE随机对照试验的数据.
- 对PCSK9-mAbs和HAEs最近的分析的审查.
- 考虑对PCSK9遗传多态和变异的研究.
主要成果:
- 在FOURIER-OLE试验中,长期使用PCSK9-mAb (8年以上) 时,HAE的发病率没有增加.
- 最近的元分析表明PCSK9-mAbs和HAE之间没有显著的关系.
- PCSK9遗传因素可能会影响HAE,但不建议进行常规遗传检测.
结论:
- 目前的证据表明PCSK9-mAbs和HAEs之间没有显著的关联.
- 需要长期的后续研究来最终证实这些发现.
- 在开始PCSK9-mAb治疗之前,不需要对PCSK9变异进行遗传测试.
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