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在复发的头癌中,类似干细胞的T细胞减少免疫微环境

Linda Chen¹, Nancy Lee¹, Reith Sarkar¹

¹Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

|July 12, 2023

概括

复发的HPV相关的头癌显示出一个低炎症的瘤微环境. 这种特征是较少的干状T细胞,损害了抗瘤免疫反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
头部和部癌症研究研究

背景情况:

人类乳头瘤病毒 (HPV) 相关的头癌会创造一个富有免疫力的瘤微环境.
与HPV相关的头癌复发后治疗中的免疫微环境尚不清楚.

研究的目的:

为了研究免疫细胞组成和空间分布在化学放射治疗后复发的HPV相关的头癌.
为了比较原发性瘤的瘤微环境与配对的复发性瘤.

主要方法:

多复合免疫光学使用12个标记物跨越两个面板.
分析了27个瘤样本 (18个主要,9个复发).
半自动数字病理学用于细胞表型,定量和空间分析.

主要成果:

在复发之前的初始瘤显示瘤相关的巨细胞和免疫排除的表型的丰富.
复发的瘤呈现出低炎症状态,干状TCF1+CD8T细胞显著减少.
干状T细胞的减少表明T细胞驱动的抗瘤免疫能力下降.

结论:

复发性HPV相关的头癌显示出一个免疫微环境与减少的抗瘤T细胞反应.
干状T细胞的减少可能解释了在复发性疾病中免疫监测的受损.

关键词:

这是一个HPVHPVHPV.在TCF1+T细胞中.化学辐射的发生.头部和部癌症头部和部癌症经常性的反复的反复.瘤免疫的微环境

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