在新生儿的持续性肺高血压中,扩张性心室功能
Kévin Le Duc1,2,3, Thameur Rakza1,3, Jean Benoit Baudelet4
1Department of Neonatology, Pôle Femme-Mère-Nouveau-Né, Hôpital Jeanne de Flandre, Centre Hospitalier Universitaire de Lille, Lille, France.
Frontiers in pediatrics
|July 12, 2023
概括
新生儿持续性肺高血压 (PPHN) 与透缩右心室功能障碍有关,而不是静脉功能障碍或肺动脉压力. 这种扩张性功能障碍可能会导致PPHN婴儿的呼吸衰竭.
科学领域:
- 新生儿心脏病学 新生儿心脏病学
- 儿科肺病学 儿科肺病学
- 心脏生理学 心脏生理学
背景情况:
- 新生儿持续性肺高血压 (PPHN) 通常被视为循环问题,心脏功能障碍的作用不太清楚.
- 新生儿对肺高血压的耐受性可能取决于双心室功能.
研究的目的:
- 评估无症状肺高血压的健康新生儿和患有PPHN的新生儿的双心室心脏性能.
- 研究新生儿心脏功能和肺高血压之间的关系.
主要方法:
- 组织多普勒成像 (TDI) 和常规回声心脏成像用于评估心脏功能.
- 研究了10名患有PPHN的新生儿和10名患有肺高血压的无症状健康新生儿.
主要成果:
- 抽缩性肺动脉压力和右心室自由壁抽缩速度在两组之间是相似的.
- 在PPHN组中,右心室异体体松时间显著较长 (53 ± 14 ms vs. 14 ± 4 ms).
- 在这两组中,左心室缩功能均正常.
结论:
- 新生儿肺动脉高压与右静脉功能变化或左心室功能受损无关.
- PPHN的特点是显著的右腹离心室功能障碍.
- 扩张性右心室功能障碍和从右到左的分流可能会导致PPHN的低氧呼吸衰竭,严重程度可能与扩张性功能障碍有关,而不是肺动脉压力.
相关概念视频
Mitral Stenosis I: Introduction
18
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
18
Pulmonary Hypertension: Classification and Pathogenesis
230
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
230
Heart Failure II: Pathophysiology
16
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
16


