在COVID-19患者中氧化应激,DNA损伤和炎症
Guven Bektemur1, Kubra Bozali2, Sahin Colak3
1Department of Public Health, University of Health Sciences Turkiye, Hamidiye Faculty of Medicine, Istanbul, Turkiye.
Northern clinics of Istanbul
|July 12, 2023
概括
COVID-19患者表现出增加的氧化应激,炎症和DNA损伤. 这些生物标志物,包括总氧化剂状态 (TOS) 和IL-6等炎症性细胞因子,是升高的,而抗氧化剂水平降低,影响疾病预后.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- COVID-19与严重的炎症和氧化压力有关.
- 这些条件导致患者的组织损伤,氧化损伤和DNA损伤.
- 了解这些生物标志物对于管理COVID-19至关重要.
研究的目的:
- 研究COVID-19患者的氧化应激,DNA损伤和炎症生物标志物.
- 为了比较COVID-19患者和健康个体之间的这些生物标志物.
主要方法:
- 分析了150名COVID-19患者和150名健康对照者的血液样本.
- 光度方法测量了总氧化剂状态 (TOS),总抗氧化剂状态 (TAS),总醇 (TT) 和髓氧化酶 (MPO) 活性.
- 使用ELISA和彗星测定来评估炎症标记物 (TNF-α,IL-1β,IL-6) 和基因毒性.
主要成果:
- 在COVID-19患者中,氧化应激标志物 (二硫化物,TOS,MPO,氧化应激指数) 和炎症标志物 (IL-1β,IL-6,TNF-α) 的水平显著增加 (p<0.001).
- 在COVID-19患者中,DNA损伤显著增加 (p<0.001).
- 抗氧化剂标志物 (TAS,TT,NT) 在COVID-19患者中显著下降 (p<0.001).
结论:
- 诱导的DNA损伤,炎症和氧化应激是COVID-19的特征.
- 这些生物标志物可能会指导COVID-19的预后和治疗策略.
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