在治疗大麻使用障碍时使用迷幻药的系统审查和理由
Angela N Phan1, Garth E Terry2,3
1University of Washington School of Medicine, Seattle, WA, United States.
Frontiers in psychiatry
|July 12, 2023
概括
关于大麻使用障碍 (CUD) 的迷幻药的研究有限. 虽然有希望,但潜在的风险如精神病和心血管事件需要在CUD人口中仔细考虑.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 大麻使用障碍 (CUD) 影响2%至5%的美国成年人,由于限制减少和THC含量增加,患病率越来越高.
- 目前,尽管进行了广泛的药物试验,但对于CUD没有FDA批准的药物.
- 迷幻药在其他物质使用障碍中显示出治疗潜力,引发了对CUD应用的兴趣.
研究的目的:
- 审查关于CUD或CUD风险人群中迷幻药的使用现有文献.
- 探索心理药物作为CUD治疗的潜在理由和机制.
主要方法:
- 在多个数据库中进行了系统的文献搜索.
- 纳入标准侧重于对人类CUD治疗中迷幻药物的初级研究.
- 排除标准删除了没有报告大麻使用或CUD风险变化的研究.
主要成果:
- 这项搜索产生了305个独特的结果,其中有一项关于CUD胺的研究和三个主题相关的文章.
- 为了背景,安全性和合理性,审查了额外的文献.
- 关于专门用于CUD的迷幻药物的使用数据仍然有限.
结论:
- 鉴于CUD的发病率和兴趣的增加,迫切需要对CUD的迷幻药进行更多研究.
- 迷幻药通常具有很高的治疗指数,但CUD特定的风险 (精神病,心血管事件) 需要仔细评估.
- 对于CUD而言,迷幻药的潜在治疗机制需要进一步调查.
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