在异构血型造血干细胞移植后的捐赠细胞白血病
Ahmed Khattab1,2, Sunita Patruni3, Gina Patrus4
1Department of Medical Oncology and Hematology, Allegheny Health Network, Pittsburgh, PA, USA.
Journal of hematology
|July 12, 2023
概括
捐赠细胞白血病 (DCL) 是异构干细胞移植 (SCT) 后的一种罕见并发症. 这项研究强调了SCT后捐赠细胞异常的四个病例,强调了临床特征和挑战.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植科学 移植科学
背景情况:
- 全球范围内,异构干细胞移植 (SCT) 越来越多地进行.
- 移植后的供体细胞病理,包括供体细胞白血病 (DCL),是一种严重的并发症.
- 早期发现供体细胞异常可以为供体选择和生存计划提供信息.
研究的目的:
- 呈现所有原型造血干细胞移植 (HSCT) 接受者的捐赠细胞异常的临床特征和挑战.
- 为了强调DCL的发生是罕见但重要的移植后并发症.
主要方法:
- 病例系列介绍了四名在异构SCT后发展出供体细胞异常的患者.
- 对临床特征和结果的审查.
主要成果:
- 四名患者在异构HSCT后出现了捐赠细胞异常.
- 该研究强调了与这些罕见事件相关的临床表现和管理挑战.
结论:
- 捐赠细胞异常,包括DCL,是异构SCT的罕见但至关重要的并发症.
- 对预测和检测捐赠细胞病理的进一步研究是有必要的,以改善患者的生存率.
更多相关视频
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
14.6K
08:05Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
7.9K
相关概念视频
Bone Marrow Sampling and Transplants
360
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
360
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Tissue Transplantation
408
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
408
