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Updated: Jul 23, 2025

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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在癌症中对体突变和基因重组的单细胞多基因鉴定

Susan M Grimes1, Heon Seok Kim1, Sharmili Roy1

  • 1Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

NAR cancer
|July 12, 2023
PubMed
概括

这项研究引入了一种新的单细胞方法,用于基因组化信使RNA (mRNA) 的体位突变,并将其与细胞转录组联系起来. 该技术能够准确地识别癌症样本中的遗传变异和重组.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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