气体辅助的微流体级别乳化,用于产生微米和亚微米大小的液滴
Biao Huang1, Xinjin Ge2, Boris Y Rubinstein3
1Department of Aerospace Engineering, Beijing Institute of Technology, No. 5 ZhongGuanCunNan Street, HaiDian District, Beijing, 100081 China.
Microsystems & nanoengineering
|July 12, 2023
概括
一种新的气体辅助方法为生物医学用途创造了统一的亚微米滴. 这种技术提高了生产速度,并允许粘性液体的乳化,克服了以前微流体方法的局限性.
科学领域:
- 微流体学 微流体学
- 乳化科学是一种乳化科学.
- 生物医学工程 生物医学工程
背景情况:
- 微米和亚微米大小的液滴对于生物医学诊断和药物输送至关重要.
- 现有的微流体共流阶段乳化方法在滴滴大小控制和生产速度方面存在局限性,特别是对粘性液体.
- 滴滴直径受到微通道高度的约束,生产速度受到毛细血管数量的限制.
研究的目的:
- 开发一种新的气体辅助同流阶段乳化方法,用于增强滴滴生成.
- 为了克服传统的全液体双相阶段乳化制剂的局限性.
- 为了实现更高的生产速度和乳化高粘度液体.
主要方法:
- 使用空心空气/油/水乳液开发了一种气体辅助的同流阶段乳化技术.
- 空气作为最内层的相向外扩散,导致油滴的形成.
- 该方法利用三相阶段乳化缩放规律来控制滴滴大小.
主要成果:
- 这种新的方法实现了标准双相方法无法达到的最小滴滴大小,达到.
- 每个频道的生产率比标准方法高出一个数量级,比替代方法优越.
- 由于气体粘度低,该技术成功地从高粘度流体中产生了微米和亚微米大小的液滴.
结论:
- 气体辅助的同流阶段乳化方法提供了一种多功能和高效的方法,用于生产均的微米和亚微米大小的滴.
- 这种方法显著提高了生产速度,并扩大了对高粘度液体的适用性.
- 该技术有望在生物医学诊断和药物输送方面推进应用.
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