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两个化复合体作为MR应用中的分子温度传感器

Felix Mysegaes^1,2, Pauline Voigt², Peter Spiteller²

¹Institute of Biometry and Medical Informatics, Otto von Guericke University Magdeburg, Medical Faculty, Leipziger Str. 44, Magdeburg 39120, Germany. markus.plaumann@med.ovgu.de.

Chemical communications (Cambridge, England)

|July 12, 2023

概括

新的 (Tm³⁺) 复合体使得使用-19 (¹⁹F) 磁共振成像进行温度检测. 这种进步克服了标准质子 (H) MRI 的局限性,提供了无参考温度传感方法.

科学领域:

无机化学无机化学
生物医学成像技术生物医学成像技术
材料科学材料科学材料科学

背景情况:

标准的质子 (H) 磁共振 (MR) 成像在某些应用中面临挑战.
-19 (F) MR为克服这些局限性提供了独特的优势.
生物系统中的温度传感对于各种医疗应用至关重要.

研究的目的:

为F MR应用合成和表征新型 (Tm3+) 复合物.
评估这些复合体作为温度传感器的潜力.
评估合成复合物的细胞活力和稳定性.

主要方法:

两个不同的Tm³⁺复合物的合成.
综合体的表征,包括光谱分析.
使用标准测试评估细胞活力.
在相关条件下评估复杂稳定性.
使用F MR光谱的温度依赖测量.

主要成果:

成功合成和表征了两个Tm3+复合体.
对于两个复合体的F NMR中,已经证明了温度依赖的化学变化 (ΔCT = -0.2319 ppm K-1和 -0.2122 ppm K-1).
这两种复合体都表现出良好的细胞活力和稳定性.
这些复合物作为有效的温度探针而起作用,而不需要参考化合物.

结论:

开发的TM3+复合体是基于FMR的温度成像的有希望的候选者.
这些综合体为非侵入性温度监测提供了一种新的,无参考方法.
需要进一步研究它们在生物医学环境中的应用.

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