在退伍军人卫生管理局患者中,处方药与可执行的药物基因组建议
Saba Maghari1, Tyler Gallo2, Salvador Rivas1
1Phoenix VA Health Care System, Phoenix, AZ 85012, USA.
Pharmacogenomics
|July 12, 2023
概括
药物遗传学 (PGx) 测试显示,对超过三分之一的处方给退伍军人卫生管理局患者的药物,有可行的安全性和有效性建议. 许多接受PGx测试的患者被处方给了可能受到这些遗传见解影响的药物.
科学领域:
- 药物基因组学 药物基因组学
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物遗传学 (PGx) 测试可以指导药物选择和剂量,以提高安全性和有效性.
- 了解可操作的PGx建议在现实世界临床环境中的普遍性对于实施至关重要.
- 退伍军人卫生管理局 (VHA) 提供了大量的患者群体来研究PGx集成.
研究的目的:
- 为了确定可操作的药物基因组学 (PGx) 安全性和疗效性建议的药物的使用频率.
- 评估PGx结果与临床药物遗传学实施联盟 (CPIC) 在药物不良反应 (ADR) 患者的指导方针的一致性.
- 评估PGx测试对VHA内药物处方的影响.
主要方法:
- 对门诊处方数据 (2011-2021) 和已记录的副作用的回顾性审查.
- 分析包括在VHA地点接受PGx测试的患者 (2019年11月-2021年10月).
- 根据CPIC处方指南确定了可执行的建议.
主要成果:
- 32.8%的审查处方有可执行的PGx建议 (共381个).
- 可采取行动的建议分为有效性 (17.7%) 和安全性 (15.2%) 问题.
- 在患有PGx影响药物的副作用的患者中,39.1%的PGx结果与CPIC指南一致.
结论:
- 经常处方具有可操作的PGx安全性和有效性建议的药物.
- 在城VHA接受PGx测试的患者中,很大一部分接受了可能受PGx结果影响的药物.
- 研究结果支持将PGx信息纳入个性化医学的常规临床实践.
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