日间皮质醇在自闭症和神经类型青少年的发展轨迹
Blythe A Corbett1,2,3, Trey McGonigle4, Rachael A Muscatello1
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Development and psychopathology
|July 12, 2023
概括
自闭症年轻人表现出改变的白天皮质醇模式,与神经典型的同龄人相比,斜坡更平,晚上水平更高. 这些下丘脑-垂体-上腺 (HPA) 轴的差异受年龄,青春期和性别的影响.
科学领域:
- 神经内分泌学神经内分泌学
- 发展心理学 发展心理学
- 自闭症谱系障碍研究研究
背景情况:
- 脑下垂体-垂体-上腺 (HPA) 轴随着年龄和青春期的成熟而成熟,这影响了对抑郁症等精神疾病的脆弱性.
- 自闭症谱系障碍 (ASD) 与社会挑战,HPA轴失调和抑郁风险增加有关,这表明在发育过程中脆弱性增加.
- 关于自闭症青少年在关键性青春期过渡期间的HPA轴成熟模式的研究有限.
研究的目的:
- 纵向检查青春期中自闭症与神经类型青少年的白天皮质醇模式.
- 确定年龄和青春期对白天皮质醇轨迹的贡献.
- 在自闭症和神经类型青年中研究HPA轴调节的潜在性别差异.
主要方法:
- 纵向评估自闭症和神经类型青年在青春期过渡期间的白天皮质醇水平.
- 统计分析比较皮质醇表达,白天的斜率,和晚上的水平之间的组.
- 探索年龄,青春期和性别作为影响HPA轴成熟的因素.
主要成果:
- 与神经类型的年轻人相比,自闭症年轻人表现出较浅的白天皮质醇倾斜和较高的晚上皮质醇.
- 在两组中,皮质醇水平和节律平整与年龄和青春期发育有关.
- 女性,在自闭症和神经类型组中,比男性表现出更高的皮质醇,更平坦的斜坡和较高的晚上皮质醇.
结论:
- 青春期期间HPA轴的成熟受到自闭症谱系障碍诊断的重大影响.
- 年龄,青春期状态和性别是HPA轴活动和白天皮质醇节律的关键调节者.
- 研究结果突出了自闭症青少年独特的神经内分泌特征,强调了需要量身定制的发育和临床考虑.
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