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通过LRP8介导的单半氨酸吸收是MYCN增强神经母细胞瘤中可准的漏洞

Hamed Alborzinia1,2, Zhiyi Chen3, Umut Yildiz1,2,4

  • 1Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.

EMBO molecular medicine
|July 12, 2023
PubMed
概括

研究人员发现,LRP8保护MYCN增强的神经母细胞瘤细胞免受铁亡. 删除LRP8通过限制GPX4的来触发铁亡,为神经母细胞瘤提供了潜在的治疗方法.

关键词:
铁性化 (ferroptosis) 是一种神经母细胞瘤的神经母细胞瘤单半氨酸是一种单半氨酸.单蛋白是一种单蛋白.合成杀伤性 合成杀伤性

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