绿茶 (GT) 多和人类肠道细菌之间的双向相互作用
Se Rin Choi1, Hyunji Lee1, Digar Singh1
1Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.
Journal of microbiology and biotechnology
|July 12, 2023
概括
绿茶中的多被肠道微生物转化为增强抗氧化活性的新化合物. 这些化合物对肠道细菌产生影响,抑制一些,同时允许有益的乳杆菌物种壮成长.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 绿茶 (GT) 多在胃肠道 (GIT) 中被广泛代谢.
- 肠道微生物酶在生物转化GT多中起着至关重要的作用,影响其生物活性和生物可用性.
- 了解这些相互作用是利用GT的健康益处的关键.
研究的目的:
- 为了研究37个人类肠道微生物群和GT多之间的体外相互作用.
- 为了确定参与GT多代谢的特定肠道细菌.
- 评估GT多及其衍生物对肠道微生物生长和抗氧化活性的影响.
主要方法:
- 在实验室内用GT多来化37种人类肠道微生物群.
- 培养提取物的UHPLC-LTQ-Orbitrap-MS/MS分析.培养提取物的UHPLC-LTQ-Orbitrap-MS分析.
- 测量抗氧化剂的生物活性,并评估对细菌生长率的影响.
主要成果:
- 属 *Adlercreutzia*, *Eggerthella* 和 *Lactiplantibacillus plantarum* 促进了 GT 儿茶素中的 C 环开放.
- *L. plantarum*水解的甲基素烯酸乙和转换的黄类糖化物.
- 生物转化GT聚醇表现出增强的抗氧化活性,并抑制了Actinobacteria,Bacteroides和Firmicutes,节省了Lactobacillus*.
结论:
- 肠道微生物群显著生物转化GT多,产生具有改变生物活性的衍生物.
- 特定的肠道细菌,如L. plantarum,是GT多代谢的关键参与者.
- GT多及其衍生物调节肠道微生物组合,对宿主健康有潜在影响.
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