周围蛋白是外周神经系统疾病中轴突损伤的生物标志物
Stephen Keddie1,2,3, Duncan Smyth2,3, Ryan Y S Keh2,3
1Department of Neuromuscular Diseases, Barts Health NHS Trust, London E1 1BB, UK.
Brain : a journal of neurology
|July 12, 2023
概括
周围蛋白显示为周围神经损伤的特定血液生物标志物有前途,与神经丝光链不同. 这种新的标志物准确地反映了在诸如吉兰-巴雷综合征等疾病中发生的急性轴突损伤.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 外围神经系统疾病 外围神经系统疾病
背景情况:
- 目前用于外围神经损伤的血液生物标志物缺乏特异性.
- 神经纤维光链 (NfL) 对外周神经系统 (PNS) 损伤敏感,但不特异.
- 周围蛋白是一种中间丝蛋白质,主要表达在外围神经轴突中.
研究的目的:
- 为了研究外周蛋白作为一种特定的血液生物标志物,用于PNS轴突损伤.
- 为了比较外周蛋白和NfL作为各种神经疾病中的生物标志物.
主要方法:
- 开发了一种单分子阵列免疫试验,用于血清周边蛋白检测.
- 测量了Guillain-Barré综合征 (GBS),慢性炎症性脱髓化多基原核神经病 (CIDP),多发性硬化症,痴呆症和健康对照患者的纵向血清外周蛋白和NfL水平.
- 分析了组织分布和体外神经损伤模型.
主要成果:
- 周围蛋白主要局限于周围神经轴突和脊髓.
- 与所有其他组相比,GBS患者的血清周围蛋白水平显著更高.
- 周围素水平在急性GBS中显示出快速上下降的模式,在第一周内达到顶峰,与NfL不同,NfL以后达到顶峰.
结论:
- 血清外周蛋白是急性PNS轴突损伤的有希望的,动态的和特定的生物标志物.
- 与NfL相比,Peripherin在PNS轴突损伤方面提供了更大的特异性.
- 环素可以改善PNS疾病的管理.
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