基于非编码RNA的高KIF26B表达与结肠癌的预后不佳和瘤免疫透相关
Zhihong Liu1, Xin Zhou1, Bo Chen2
1Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Cell cycle (Georgetown, Tex.)
|July 12, 2023
概括
素家族26B成员 (KIF26B) 在结肠腺癌 (COAD) 中被上调,与预后不佳和免疫透增加相关. 这种ncRNA驱动的KIF26B表达影响瘤免疫力和患者的生存率.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 素家族26B成员 (KIF26B) 在各种癌症中表现异常.
- 在结肠腺癌 (COAD) 中KIF26B的特定作用及其与瘤免疫透的关联仍然在很大程度上未被描述.
研究的目的:
- 为了研究KIF26B在COAD中的表达模式.
- 确定KIF26B表达与临床结果,免疫透和COAD中的调节途径之间的相关性.
主要方法:
- 使用TCGA,UCSC Xena,GEO,Oncomine,TIMER和HPA数据库进行表达式分析.
- 使用StarBase和RT-qPCR进行预测和验证的上游调节性ncRNA (miRNA和lncRNA).
- 通过GEPIA2和TIMER分析了与免疫相关基因,免疫细胞透和免疫检查点的相关性.
主要成果:
- 在COAD中,KIF26B显著上调,与较差的整体存活率,疾病特异性存活率和无进展间隔有关.
- 确定了MIR4435-2HG/hsa-miR-500a-3p/KIF26B轴作为一个关键的监管途径.
- KIF26B表达与免疫透,免疫细胞生物标记物和免疫检查点基因 (PDCD1,CD274,CTLA4) 有积极的相关性.
结论:
- 在COAD中异常,ncRNA驱动的KIF26B上调与不良预后有关.
- 增加KIF26B的表达与瘤免疫透的增加相关,这表明它在调节瘤微环境中的作用.
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