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与新生儿胆固醇形成相关的因素新生儿有胃

Juliana Zoboli Del Bigio¹, Ana Cristina Aoun Tannuri¹, Mário Cícero Falcão¹

¹Universidade de São Paulo, São Paulo, SP, Brazil.

Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

|July 12, 2023

概括

患有胃的新生儿经历胆固醇症可能受益于鱼油脂溶液乳液. 这一发现表明,一种潜在的饮食干预措施可以降低这些脆弱的婴儿的胆固醇形成风险.

科学领域:

新生儿科学新生儿科学
儿科手术儿科手术
临床营养学临床营养学

背景情况:

胃分裂是一种先天性腹壁缺陷,需要手术干预.
患有胃的新生儿有很高的并发症风险,包括胆固醇病.
在这种人群中,胆固醇症会导致显著的发病率和长时间住院.

研究的目的:

为了确定新生儿中胆固醇中毒的发病率.
为了确定与这种队列中胆固醇病的发展相关的风险因素.
评估不同脂质乳液对胆固醇形成风险的影响.

主要方法:

对181名患有胃的新生儿进行了回顾性队列研究 (2009-2020年).
风险因素的分析,包括妊娠年龄,出生体重,手术方法,肠道营养持续时间和脂质乳液类型.
基于脂质乳液成分 (MCT/LCT与鱼油) 的胆固醇发生率的比较.

主要成果:

在评估的新生儿中,23.3% (41/176) 患有胆固醇病.
单变量分析确定了低出生体重,早产和标准脂质乳液 (MCT/LCT) 作为危险因素.
多变量分析表明,与MCT/LCT乳液相比,基于鱼油的脂类乳液与胆固醇形成的风险较低.

结论:

基于鱼油的脂质乳液可以降低新生儿患有胃的胆固醇病的风险.
这一发现表明了潜在的营养策略,以减轻一个常见的并发症.
需要进一步的前性研究来证实这些回顾性发现.

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