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[来自吉尔吉斯斯坦的C型肝炎病毒序列中与耐药性相关的替代物的分析]

M Y Kartashov¹, K A Svirin¹, A A Bekbolotov²

¹State Research Center of Virology and Biotechnology "Vector" of Rospotrebnadzor.

Voprosy virusologii

|July 12, 2023

概括

吉尔吉斯斯坦的C型肝炎病毒 (HCV) 显示出显著的遗传多样性,常见的亚型为1b和3a. 许多隔离物携带的突变降低了对直接作用抗病毒药物 (DAA) 的敏感性,需要对有效治疗策略进行更新的监测.

科学领域:

病毒学病毒学
流行病学流行病学
遗传学遗传学是一个

背景情况:

肝炎C病毒 (HCV) 感染在中亚,包括吉尔吉斯斯坦普遍存在.
了解HCV基因型多样性和耐药性突变对于治疗和分子流行病学至关重要.

研究的目的:

调查吉尔吉斯斯坦HCV的遗传多样性.
在流通的HCV菌株中识别与对直接作用抗病毒药物 (DAA) 耐药性相关的突变.

主要方法:

分析了来自吉尔吉斯斯坦HCV感染个人的38个血清样本.
对NS3,NS5A和NS5B病毒基因片段的测序.
基因银行是确定核酸序列的沉积.

主要成果:

鉴定出HCV1b (52.6%),3a (44.8%) 和1a (2.6%) 的亚型.
与DAA耐药性相关的突变的流行:NS5A中的C316N和F37L (亚型1b),NS5A中的Y93H (亚型3a),NS3中的Y56F.
在1a亚型中没有发现DAA耐药性突变.

结论:

在来自吉尔吉斯斯坦的HCV序列中观察到DAA耐药性相关突变的高患病率.
定期更新HCV遗传多样性对于规划有效的公共卫生干预措施至关重要.

关键词:

吉尔吉斯斯坦吉尔吉斯斯坦直接作用的抗病毒药物.基因型定制是基因型定制.在C型肝炎病毒的感染中,

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