考虑冠状动脉运动对动脉特定生物力学的影响,使用流体结构相互作用模拟
Nicholas A T Fogell1, Miten Patel2, Pan Yang2
1National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, SW3 6LY, UK. n.fogell@imperial.ac.uk.
Annals of biomedical engineering
|July 12, 2023
概括
冠状动脉曲显著改变墙壁剪切应力和应力,影响动脉壁生物学. 这些流体结构相互作用模型显示,曲效应因船只而异,需要对船只进行特定的生物力学分析.
科学领域:
- 心血管生物力学心血管生物力学
- 医学成像和建模 医学成像和建模
背景情况:
- 冠状动脉内皮受壁剪压和血管壁应变的影响.
- 准确的生物力学建模对于理解动脉壁生物学至关重要.
研究的目的:
- 为冠状动脉开发和应用血管特异性流体结构相互作用 (FSI) 模型.
- 为了研究冠状动脉曲对剪切应力和张力等生物机械因素的影响.
主要方法:
- 利用直接测量的实验几何和三个冠状动脉的边界条件.
- 开发了FSI模型,包括冠状动脉曲,以模拟血液流动和血管变形.
- 与传统计算流体动力学 (CFD) 曲的和没有曲的FSI结果进行比较.
主要成果:
- 与CFD相比,具有曲的FSI模型显著改变了所有计算的剪切应力指标 (p < 0.0001).
- 曲导致不同冠状动脉的时间平均壁切削应力 (TAWSS),振荡切削指数 (OSI) 和横壁切削应力 (tSS) 的实质性变化.
- 在曲下,船壁应变从均转变为高度异构,周期性应变大小发生显著变化.
结论:
- 冠状动脉曲引入了显著的生物力学变化,影响了剪切应力和应力分布.
- 曲的影响是船舶特有的,强调需要个性化分析.
- 在对冠状动脉功能和疾病的生物力学分析中,应考虑曲.
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