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质瘤:一个全面的审查

Meryem Bektas¹, Timothy Bell², Shahnaz Khan¹

¹RTI Health Solutions, Research Triangle Park, NC, USA.

Advances in therapy

|July 12, 2023

概括

由于诊断挑战和慢性疼痛等严重症状,瘤 (DT) 构成重大负担. 需要有针对性的治疗来改善患者的生活质量.

科学领域:

在瘤学瘤学.
罕见疾病罕见疾病
临床研究临床研究

背景情况:

德斯莫体瘤 (DT) 是一种罕见的,具有攻击性的纤维细胞瘤.
透性DT生长会造成相当大的临床负担,并影响生活质量.
由于发病率低 (每百万人年3-5人),疾病意识有限.

研究的目的:

审查和综合当前对与瘤相关的疾病负担的理解.
突出诊断挑战,症状负担和生活质量影响.
识别DT管理中未得到满足的需求.

主要方法:

在PubMed,Embase,Cochrane和主要会议的系统文献搜索 (2021年11月 - 2023年3月).
从最初的651个已识别的出版物中,包括96个相关出版物.
分析重点是诊断,症状,生活质量和治疗选择.

主要成果:

由于异质性和可变的呈现,诊断具有挑战性,导致延迟.
报告的高症状负担:63%的人经历慢性疼痛,影响睡眠,情绪和功能.
生活质量明显低于健康人群.

结论:

德斯莫伊德瘤的重大负担源于诊断困难,高症状负担和生活质量的降低.
目前的治疗选择缺乏特定的FDA对DT的批准.
对新的,有针对性的疗法有很高的未满足需求,以改善患者的治疗结果和生活质量.

关键词:

侵袭性纤维肌瘤的发生.这是一个沉重的负担.这种瘤是Desmoid瘤.流行病学流行病学生活质量生活的质量.这是软组织瘤.

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