氨酸类型的三三烯桑波宁的新生物功能作用
Hisashi Matsuda1,2, Toshio Morikawa3, Seikou Nakamura4
1Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8412, Japan. matsuda_134@outlook.jp.
Journal of natural medicines
|July 12, 2023
概括
氨酸类型的三三素氨酸表现出新的生物功能作用,包括调节血液中酒精和葡萄糖水平,并影响胃肠功能. 这些沙素显示出对控制肥胖和保护胃病变的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 胃肠病学 胃肠病学
背景情况:
- 氨酸类型的三烯素是具有多种生物活性的天然化合物.
- 这些来源包括Aralia elata,Kochia scoparia,Polygala senega,Camellia japonica和Aesculus hippocastanum. 这些植物的种类有:
研究的目的:
- 审查oleanane类型三三番的新生物功能作用.
- 探索它们对血中酒精,葡萄糖,胃排空,胃肠道过境,胃粘膜病变和肥胖的影响.
主要方法:
- 关于氨酸型三二烯素的现有文献的综述.
- 在动物模型 (老鼠和小鼠) 中分析生物功能活动.
- 基于化学结构的活性沙因的分类.
主要成果:
- 沙素对血液中酒精和葡萄糖水平表现出抑制作用.
- 它们影响了胃排空和胃肠道过渡.
- 观察到对胃粘膜病变和肥胖 (通过抑制食物摄入) 的保护作用.
- 活性沙素被分为三个结构类型.
结论:
- 一种共同的作用机制,可能涉及素敏感的神经,氧化 (NO),前列腺素 (PG) 和交感神经,可能会调解药理效应.
- 胃肠道是这些沙素作用的关键部位.
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