诊断低剂量X射线辐射诱导病原性细菌在诺基诺隆耐药性
Jaouhra Cherif1, Anis Raddaoui2, Meriam Trabelsi3
1Laboratory of Biophysics and Medical Technologies, Higher Institute of Medical Technologies of Tunis, University of Tunis El Manar, Tunis, Tunisia.
International journal of radiation biology
|July 12, 2023
概括
暴露于诊断性X射线辐射可以增加细菌对抗生素的耐药性. 低剂量X射线显著降低了常见抗生素如马尔博素和青素在致病细菌中的有效性.
科学领域:
- 微生物学 微生物学
- 辐射生物学 辐射生物学
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性是全球主要的健康危机.
- 虽然过度使用抗生素是已知的驱动因素,但身体压力因素也可以诱导耐药性.
- 诊断X射线辐射对细菌抗生素敏感性的影响尚不清楚.
研究的目的:
- 调查低剂量诊断X射线辐射对黄金葡萄球菌 (Staphylococcus aureus) 和沙门氏菌 (Salmonella enteritidis) 抗生素敏感性的影响.
- 为了确定X射线暴露是否影响细菌生长动态和对抗生素的反应.
主要方法:
- 暴露于S.S.的时间 黄金色和S. 黄金色和S. 对诊断性X射线剂量 (5和10mGy).
- 辐射后细菌生长动态的评估.
- 用各种抗生素的抑制区测量进行抗生素敏感性测试.
主要成果:
- 对两种物种来说,X射线暴露增加了可行的细菌殖民地.
- 观察到对抗生素敏感性的显著变化.
- 马博素,青素,阿莫西西林和阿莫西西林/克拉夫兰酸的抑制区在辐射后显著减少.
结论:
- 诊断低剂量X射线辐射显著改变细菌对抗生素的敏感性.
- 暴露于X射线会降低诺和β-乳糖抗生素的疗效.
- 这项研究突出了一个潜在的,被低估的因素,有助于抗生素耐药性的发展.
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