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Updated: Jun 27, 2026

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一个基于基因表达的生物剂量测量的简化协议,使用外周全血

Shuchi Bhagi1, Sudhir Chandna1

  • 1Division of Molecular & Radiation Biosciences, Institute of Nuclear Medicine & Allied Sciences (INMAS), Defence Research & Development Organization (DRDO), Brig SK Mazumdar Marg, Delhi, 110054, India.

International journal of radiation biology
|July 12, 2023
PubMed
概括

在37°C的温度下将全血化24小时,优化了对辐射敏感基因表达的生物对称性. 这种方法提高了辐射剂量评估的灵敏度,特别是DDB2和FDXR基因.

关键词:
辐射生物对称学基因表达的基因表达方式辐射反应基因对辐射有反应的基因.储存温度 储存温度 储存温度没有改变的全血.

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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...