消化道平:一个描述性的多中心报告.
Elizabeth S Aby1, Jason D Eckmann1, Jad Abimansour2
1Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition.
Journal of clinical gastroenterology
|July 12, 2023
概括
食道平坦 (ELP) 是一种罕见的疾病,经常被忽视. 这项研究强调了它的特征,频繁的狭窄和多种治疗方法,强调了需要更好的诊断怀疑和进一步研究有效治疗的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 食道平坦 (ELP) 是一种罕见的疾病,经常被误诊.
- 关于这种患者群体的数据有限,主要来自小型的单中心研究.
研究的目的:
- 描述ELP患者的临床特征,治疗策略和结果.
- 确定ELP的常见内镜发现和管理方法.
主要方法:
- 进行了一项多中心,回顾性描述性研究.
- 分析了5年 (2015-2020年) 的7个美国中心的数据.
- 包括78名被诊断患有ELP的成年患者.
主要成果:
- 这项研究包括78名患者 (65岁,86%为女性,90%为白人).
- 超过一半的人患有食道外表现. 食道狭窄 (54%) 和异常的粘膜 (50%) 是常见的内镜检查结果.
- 局部类固醇和质子抑制剂是主要治疗方法;类固醇显示出更好的内镜反应. 近一半的患者需要改变治疗方法.
结论:
- 高的怀疑指数和活检对于诊断ELP至关重要,特别是在食道外参与的情况下.
- 有效的疗法是有限的和不同的;需要前性研究来确定最佳的治疗方案.
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