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Updated: Aug 5, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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通过in silico设计改善了HIV-1中和范围和V2-apex抗体的强度

Graham T Holt1, Jason Gorman2, Siyu Wang3

  • 1Department of Computer Science, Duke University, Durham, NC, USA; Program in Computational Biology & Bioinformatics, Duke University, Durham, NC, USA.

Cell reports
|July 12, 2023
PubMed
概括

针对艾滋病毒的工程广泛中和抗体 (bNAbs) 显示出超过100倍的增强效力和改善的宽度,为抗体设计针对艾滋病毒感染提供了新的策略.

关键词:
CP: 免疫学 免疫学CP: 微生物学 微生物学艾滋病病毒 艾滋病病毒 艾滋病病毒一个叫的.抗体设计 抗体设计提高抗体的改善.广泛中和抗体的抗体.在形设计中.蛋白质设计 蛋白质设计可以证明的算法.结构生物学结构生物学

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Inhibitors of Virion Maturation and Assembly01:19

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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...