评估药物遗传检测在军事卫生系统中的临床效用
Lydia D Hellwig1,2,3, Clesson Turner4, Cara Olsen5
1The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Military medicine
|July 12, 2023
概括
药物遗传学 (PGx) 测试显示,大多数军事卫生系统受益者都有影响药物代谢的遗传变异. 这凸显了个性化医疗的必要性,以防止MHS患者的不良药物反应.
科学领域:
- 药物基因组学 药物基因组学
- 临床遗传学 临床遗传学
- 个性化医疗是个性化的医疗.
背景情况:
- 个体对药物的反应有很大差异,导致潜在的不良药物反应.
- 药物遗传学 (PGx) 测试可以根据遗传因素预测药物反应和不良事件风险.
- 在军事卫生系统 (MHS) 中对PGx实施的研究有限.
研究的目的:
- 评估MHS受益者的药物遗传发现的流行率和可操作性.
- 评估PGx测试对军事医疗机构药物管理的潜在影响.
主要方法:
- 一项涉及165名成人MHS受益人在一家初级保健诊所的横截面研究.
- 对CYP2C19和CYP2D6基因进行PGx基因定型.
- 将基因型定型结果与临床药物遗传实施联盟 (CPIC) 准则进行比较.
主要成果:
- 81.2%的参与者至少有一个异常的PGx发现CYP2C19或CYP2D6.
- 65%的那些有异常发现的人正在服用与CPIC相关的基因药物指南相关的药物.
- 所有参与者的78%正在服用由CYP2C19或CYP2D6代谢的药物,并遵循相关的CPIC指南.
结论:
- 很大一部分MHS患者有可操作的PGx发现,这表明个性化药物管理的潜在好处.
- 许多MHS受益者正在服用因其遗传构成而可能造成不良事件的药物.
- 在MHS中实施PGx测试可以提高患者的安全性,并通过适当的基础设施优化药物治疗.
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